Total alkaloid concentration, percentage water, crude protein, and neutral detergent fiber in velvet lupine (Lupinus leucophyllus Dougl. # LUPLE) were monitored for 3 weeks following application of herbicides registered or soon to be registered for rangeland use. Picloram (4-amino-3,5,6-trichloro-2-pyridinecarboxylic acid), dicamba (3,6-dichloro-2-methoxybenzoic acid), and clopyralid (3,6-dichloro-2-pyridinecarboxylic acid) caused some signs of epinasty but did not kill velvet lupine. Total alkaloid concentration and nutrient quality of velvet lupine leaves treated with these herbicides was not significantly different from untreated plants. Esters of 2,4-D [(2,4-dichlorophenoxy)acetic acid] and 2,4,5-T [(2,4,5-trichlorophenoxy)acetic acid] and triclopyr {[(3,5,6-trichloro-2-pyridinyl)oxy]acetic acid} killed most velvet lupine plants and caused a subsequent decrease in total alkaloid concentration, crude protein, and water content as the plants desiccated. Herbicides that effectively killed velvet lupine decreased alkaloid levels, thus lowering the potential for increased livestock poisoning.