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  • 32 - Biomimetic design of neural prostheses

  • from Section B4 - Translational research: application to human neural injury
    • By Gerald E. Loeb, Department of Biomedical Engineering and the A.E. Mann Institute for Biomedical Engineering, University of Southern California, Los Angeles, CA, USA, Cesar E. Blanco, Department of Biomedical Engineering and the A.E. Mann Institute for Biomedical Engineering, University of Southern California, Los Angeles, CA, USA
  • Edited by Michael Selzer, University of Pennsylvania, Stephanie Clarke, Université de Lausanne, Switzerland, Leonardo Cohen, National Institute of Mental Health, Bethesda, Maryland, Pamela Duncan, University of Florida, Fred Gage, Salk Institute for Biological Studies, San Diego
  • Book:
    Textbook of Neural Repair and Rehabilitation
    Published online:
    05 March 2012
    Print publication:
    16 February 2006, pp 587-601

  • Summary

    This chapter deals with the neural prosthetic devices that integrate directly with the nervous system. The individual computational elements of the nervous system, neurons, are physically small in diameter, allowing them to be packed together into dense nerve tracts and nuclei. In order to achieve biomimetic function, it is desirable to exchange information with neurons on a similar spatial scale. Improving the biomimetic function of a neural prosthesis generally depends on packing yet more electrodes and signal processing functionality into ever-smaller places in the body from which they are not easily retrieved. The seemingly mundane requirements for packaging are likely to remain limiting factors in the clinical performance of neural prostheses. Many neurological deficits involve loss of function in central rather than peripheral pathways, such as inability to store or access information in various forms of dementia.