In 1987 and 1988, effects of full-season interference of individual weeds on cotton yield were measured with area of influence procedures. In 1987, one spurred anoda, common cocklebur, large crabgrass, jimsonweed, common lambsquarters, redroot pigweed, common ragweed, or prickly sida plant per 3 m of row reduced cotton yield between 1% and 7%. Sicklepod did not cause a detectable yield loss. Redroot pigweed, common cocklebur and common ragweed caused 7%, 6% and 5% yield loss, respectively, in 1987. In row weed influence varied from 17 cm (large crabgrass interference) to 86 cm (common cocklebur interference). In 1988, yield losses by individual weeds ranged from 3% to 27%. Common cocklebur, jimsonweed, and common ragweed reduced cotton yields 28%, 15% and 12%, respectively. Spurred anoda and common cocklebur influenced 160 cm and 136 cm of cotton row, respectively. Sicklepod influenced only 47 cm of cotton row.