The response of several spring wheat (Triticum aestivum L.), barley (Hordeum vulgare L.), and oat (Avena sativa L.) cultivars to preemergence and postemergence applications of chlorsulfuron (tested under code number DPX-4189) {2-chloro-N-[[(4-methoxy-6-methyl-1,3,5-triazin-2-yl)aminocarbonyl] benzenesulfonamide} was evaluated in the field and greenhouse in 1979. In greenhouse experiments, ‘Butte’ spring wheat was less susceptible than six other spring wheat cultivars to chlorsulfuron at 1.0 kg/ha applied preemergence or postemergence. ‘Morex’, ‘Conquest’, and ‘Bonanza’ barley cultivars were less susceptible than six other barley cultivars to preemergence chlorsulfuron, but barley cultivars were similar in response to postemergence chlorsulfuron. The eight oat cultivars responded similarly to preemergence and postemergence chlorsulfuron at 1.0 kg/ha. Data from two field experiments, which included evaluation of durum wheat [Triticum durum (Desf.)] cultivars, indicated that the four small grains had adequate tolerance to postemergence chlorsulfuron at 0.125 and 0.25 kg/ha, except that durum wheat grain yield was reduced by 0.25 kg/ha at the Rosemount location. No differential cultivar responses to chlorsulfuron occurred among the small grains in the field.