Field studies were conducted to evaluate the influence of herbicide application timing on weed control in no-till soybean production. Row spacing generally had no effect on weed control. Herbicide treatments containing chlorimuron plus metribuzin applied as many as 45 days prior to planting in 1988 and 1989 controlled broadleaf weeds throughout the growing season. Imazaquin applied 45 and 30 days prior to planting provided poor control of common cocklebur in 1989. Giant foxtail control was inconsistent with all herbicide treatments. Soybean yields subsequent to early preplant herbicide applications were greater than or equal to those in which applications were made at planting when late-season weed control was adequate. Herbicides applied preemergence did not control high densities of common lambsquarters in 1989.