Laboratory studies were conducted to determine the effect of SAN 582 on the absorption, translocation, and metabolism of sethoxydim in johnsongrass and soybean. 14C-sethoxydim absorption in johnsongrass and soybean was enhanced 4 h after application when tank mixed with SAN 582. Absorption in johnsongrass increased from 18% with 14C-sethoxydim applied alone to 65% when applied with SAN 582. Absorption in soybean increased from 30% with 14C-sethoxydim applied alone to 83% when applied with SAN 582. The addition of crop oil concentrate also enhanced foliar absorption of 14C-sethoxydim. Eight hours after application, foliar absorption in johnsongrass increased from 22% with 14C-sethoxydim applied alone to 61% when 14C-sethoxydim was applied with crop oil concentrate. Foliar absorption in soybean increased from 38% with 14C-sethoxydim applied alone to 59% when 14C-sethoxydim was applied with crop oil concentrate. When 14C-sethoxydim was applied in combination with crop oil concentrate and SAN 582, foliar absorption was 84% or more in both johnsongrass and soybean 4 h after application and did not increase over time. Minor differences in translocation were observed, but these differences were not sufficient to account for the increase in foliar activity observed when SAN 582 is tank mixed with sethoxydim. SAN 582 did not affect metabolism of sethoxydim in either species. Based on these data, it appears that SAN 582 increases the efficacy of sethoxydim by enhancing foliar absorption.