Soft red winter wheat cultivars were evaluated in field experiments in Georgia for tolerance to dicamba alone and mixed with 2,4-D. Treatments reduced ‘Florida 302’ yield more than ‘Florida 301’ or ‘Coker 983’ at Tifton in 1986. Mid-tillering Florida 302 wheat was more sensitive to treatment than fully tillered wheat. In 1987, dicamba plus 2,4-D applied at mid-tillering reduced yields of all cultivars in Watkinsville. Injury and yield reductions occurred primarily when mid-tiller treatments were applied to wheat that was planted 10 or 21 days later than recommended at Tifton or Watkinsville, respectively. When applied according to labeling, dicamba or dicamba plus 2,4-D use in Georgia soft red winter wheat can reduce grain yield.