Let G be a locally compact group and let $\omega $ be a continuous weight on G. In this paper, we first characterize bicontinuous biseparating algebra isomorphisms between weighted $L^p$ -algebras. As a result, we extend previous results of Edwards, Parrott, and Strichartz on algebra isomorphisms between $L^p$ -algebras to the setting of weighted $L^p$ -algebras. We then study the automorphisms of certain weighted $L^p$ -algebras on integers, applying known results on composition operators to classical function spaces.