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  • Chapter 4 - Current Understanding of the Physiology and Histology of Human Spermatogenesis

  • from Section 2 - The Biology of Male Reproduction and Infertility
  • Edited by Douglas T. Carrell, Utah Center for Reproductive Medicine, Alexander W. Pastuszak, University of Utah, James M. Hotaling, Utah Center for Reproductive Medicine
  • Book:
    Men's Reproductive and Sexual Health Throughout the Lifespan
    Published online:
    06 December 2023
    Print publication:
    16 November 2023, pp 23-33

  • Summary

    Spermatogenesis is a complex process that ensures daily production of mature male gametes. The differentiation of spermatogonia stem cells into spermatozoa requires the unfolding of several events that are highly regulated in time and space. During spermatogenesis, which takes place inside the seminiferous tubules, germ cells undergo profound morphological rearrangement as can be observed by classical histological analysis of human testis specimens. Spermatogenesis also brings about the dramatic rearrangement of genetic makeover of developing germ cells including homologous recombination and changes in the epigenetic landscape. In this chapter the different phases of human spermatogenesis and cell types involved are described with an emphasis on their morphological arrangements. In parallel, an update on novel findings concerning the cycle of the seminiferous epithelium, the kinetic of spermatogonial compartment, and the implications of single-cell transcriptome analysis of testicular cells will be provided.