Field trials were conducted to evaluate weed control and crop safety with postemergence-applied herbicides in two cultivars of low-tannin seedling sericea lespedeza (Lespedeza cuneata). Two applications of either 2,4-D amine at 0.28 kg ae/ha or 2,4-DB amine at 0.56 kg ae/ha controlled sicklepod (Senna obtusifolia) ≥ 90%. Equivalent control of smallflower morningglory (Jacquemontia tamnifolia) required either two applications of 2,4-D or three of 2,4-DB. Three applications of either herbicide were required for comparable spotted spurge (Euphorbia maculata) control. Sericea lespedeza was not adversely affected when either herbicide was applied up to three times per season over two consecutive seasons. Tolerance to 2,4-D and 2,4-DB was equal between two sericea lespedeza cultivars. Absorption of foliar-applied 14C-2,4-D was greater in sicklepod and smallflower morningglory than in sericea lespedeza. Translocation of absorbed 14C-2,4-D was equivalent between sicklepod and sericea lespedeza but greater in smallflower morningglory than in sericea lespedeza. Absorption and translocation of foliar-applied 14C-2,4-DB was equivalent between sicklepod and sericea lespedeza. Furthermore, 14C-2,4-DB absorption was less in smallflower morningglory than in sericea lespedeza.