Tebuthiuron, picloram, hexazinone, and bromacil were evaluated at 0.5, 1.0, and 2.0 g ai or ae per plant for sacahuista control on gravelly loam soils in western Texas. Tebuthiuron applied at 2.0 g per plant killed 87% of the sacahuista, which was significantly greater mortality than that achieved with the same rate of bromacil (62%) and hexazinone (44%). The 2.0 g plant-1 rate of tebuthiuron, bromacil, and hexazinone reduced live canopies of sacahuista 88 to 98%. Picloram did not control sacahuista. Sacahuista mortality increased curvilinearly with increasing rates of tebuthiuron and bromacil, whereas the response to hexazinone was linear.