The economic feasibility of four Wyoming big sagebrush control methods: burning, spraying with 2,4-D, plowing and seeding, and rotocutting was analyzed. Perennial grass response to big sagebrush treatment was measured to estimate a treatment response function for each control method which provided the biological informational base to develop cost and benefits. Annualized present values of net additional returns for single 2,4-D and burning treatments were $1.10/ha and $1.16/ha, respectively. When big sagebrush was retreated at optimal intervals, 2,4-D and burning generated annualized net additional returns of $2.88/ha and $2.57/ha, respectively. Rotocutting was marginally feasible, and plowing was not feasible.