This article brings a pragmatic perspective to the analysis of threat perception in two important ways. First, as does the philosophical tradition of pragmatism, the article joins perception (or knowledge) together with response (action). Perception and response, knowledge and action, are inextricably linked as people learn through the creation of knowledge what is useful in the world. It is in this sense that pragmatists understand the perception and response to threats as evolved practices that are conjoined. Second, the paper explores threat perception and response under the condition of radical uncertainty. I explore the kinds of strategies leaders can use to respond to perceived threat in a context of radical uncertainty, the defining characteristic of contemporary world politics, and explore the advantages of pragmatic strategies that proceed to look for ‘what works in the world’ as provisional responses to perceived threats through iterative, ongoing experimental processes.