This chapter outlines various psychotherapeutic techniques that have proved to be effective in the treatment of functional somatic syndromes. The role of psychotherapy in the treatment of bodily diseases depends on the extent to which psychological factors play a role in their etiology and course. Cognitive-behavioral therapy (CBT) is considered to be the treatment of choice for a wide range of functional somatic syndromes. Deconstructing the patient's perception of his or her condition and developing a new, shared formulation of the illness is crucial to the success of cognitive-behavioral therapy. Chronic fatigue syndrome is used to demonstrate this technique. The treatment of functional somatic syndromes requires the coordinated efforts of a variety of health professionals to minimize duplication of medical investigations. Anxiety states and depressive episodes in particular frequently require immediate relief in order to allow and encourage the patient to participate in the psychotherapeutic relationship.