This chapter explores philanthropic partnership best practices in the post-COVID-19 world and provides insights and practical tools to identify and effectively advocate for partnerships. Historically, the philanthropic sector in the Global South has been largely siloed, with only a few foundations working together and even fewer engaged in multi-sectoral collaborations. In the case of public-private partnerships, one often hears sentiments like ‘governments are bureaucratic and they will slow us down’ or ‘businesses don’t really care about social impact projects’. The COVID-19 pandemic exposed that such silos created many of the systemic issues philanthropic foundations now face. The COVID-19 crisis will have a profound impact on philanthropy through forging more active collaboration and ensuring more equitable responses. As multiple sector experts have pointed out, the scale and the urgency of the pandemic have prompted philanthropists to engage in more active collaboration, not only with businesses and government but also with each other. This chapter shares the key elements of a successful partnership from coordinated planning to clear identification of the problem that needs to be solved. It shares ideas around the collaborative definition of success, how to measure social-impact performance, and how to align interests, values, and goals. The chapter argues that there is a critical need for clear roles and responsibilities such that each stakeholder’s strengths can be leveraged, and it emphasises the importance of transparency and continuous communication.