Stress and anxiety have been identified as among the most common reasons for sickness absence. Therefore, timely work-based well-being interventions are needed. Strengths-based Cognitive-Behaviour Therapy (CBT) approaches are of benefit therapeutically. Guided imagery approaches enable individuals utilize previous positive experiences and construct positive future templates potentially increasing the likelihood of better outcomes. One hundred and seventeen participants from a health service clinical/corporate environment participated in the Looking After Me Looking After You (LAMLAY) programme. It comprised three 3-hour or four 2-hour sessions weekly. Positive imagery and strengths-based cognitive-behavioural approaches were delivered via participant exercises and didactically. Completion rate was 77.8%; seventy-five participants (83% of completers) completed the Warwick–Edinburgh Mental Well-Being Scale (WEMWBS) pre-course (mean 46.4) and post-course (mean 52.4). Significant improvements in well-being were obtained (t = 9.32, d.f. = 74, p<0.0001, d = 0.82). An online follow-up survey demonstrated sustained improved scores on the WEMWBS (F2,223 = 17.04, p<0.001, η = 0.13). Satisfaction ratings indicated high approval levels. Participants’ well-being improved at the end of the LAMLAY programme and was sustained at follow-up. The potential impact of LAMLAY and the potential to deliver cost-effective benefits is discussed. Further development work is required including more systematic investigation over a longer term.