Dermatitis from poison ivy is a significant health problem. Considerable effort is devoted to the control of this invasive and virulent weed in urban areas. Glyphosate, triclopyr, 2,4-D, a 1 : 1 mixture of glyphosate and 2,4-D, and a 9 : 1 mixture of glyphosate and triclopyr were evaluated for poison ivy control. Each of these three herbicides and two mixtures were applied at nine or ten rates, which ranged in phytotoxicity from none to death. Poison ivy plants had been propagated and container-grown. Percent control, as determined from plant fresh weight reduction, was determined at 1 and 4 mo after treatment (MAT). Data were subjected to ANOVA followed by nonlinear regression. Rates required for 95% control at 1 and 4 MAT and the associated costs were determined for each of the three herbicides and two mixtures. Acceptable control (i.e., ≥ 95%) at 1 and 4 MAT could be obtained at a much lower cost with either triclopyr or 2,4-D than with either glyphosate alone or with the two glyphosate-containing mixtures. Nonlinear regression also was used to evaluate whether the two mixtures were interactive (i.e., synergistic or antagonistic) or not (i.e., additive). Glyphosate plus triclopyr was synergistic for control at both 1 and 4 MAT. Glyphosate plus 2,4-D was synergistic for control at 4 MAT only. However, for both mixtures, synergism was only evident at rates that controlled poison ivy ≤ 80%. Both mixtures were noninteractive at rates required for acceptable control.