In Näätänen's model of early
attention, the role of arousal in influencing the permanent
feature detection system (indexed by mismatch negativity
[MMN]) and the temporary feature-detection system
(indexed by processing negativity [PN]) is unclear.
To address this question, we investigated the effects of
the anesthetic gas nitrous oxide (N2O) on the
MMN and PN. Ten subjects performed a dichotic listening
task in which discrimination difficulty and breathing mixture
(air or 25% N2O) were manipulated factorially.
MMN, PN, N1 and P300 at Fz, Cz, and Pz, as well as reaction
time (RT), were measured. N2O had no effect
on the PN, but decreased MMN amplitude. As expected, N2O
decreased the amplitude of the N1 and P300 and increased
the latency of the P300 and RT. The dissociation of MMN
and PN by N2O suggests that this agent decreases
the ability to detect automatic stimulus change without
affecting voluntary selective attention. We interpret these
results as indicating that arousal has multidimensional
effects on early attentional mechanisms. These dimensions
can be differentiated chemically by neurotransmitters in
the reticular formation of the brain.