For two decades, stable isotope studies have documented palaeodietary transitions in the Sabana de Bogotá region of north-west South America. Using traditional and Bayesian stable isotope mixing models, this article investigates the contribution of different resources to Holocene human diets. Temporal patterns include dietary emphases on plants during the Early and Middle Holocene, on maize horticulture through the initial Late Holocene and on maize/tuber agriculture during the final Late Holocene; animal protein apparently contributed little across all periods. These results suggest that the management and selection of diverse plants occurred early, and the later emphasis on maize raises universal questions about the role of agriculture in cultural change and social differentiation.