Judgments of a treatment’s effectiveness are usually biased by the probability with which the outcome (e.g., symptom relief) appears: even when the treatment is completely ineffective (i.e., there is a null contingency between cause and outcome), judgments tend to be higher when outcomes appear with high probability. In this research, we present ambiguous stimuli, expecting to find individual differences in the tendency to interpret them as outcomes. In Experiment 1, judgments of effectiveness of a completely ineffective treatment increased with the spontaneous tendency of participants to interpret ambiguous stimuli as outcome occurrences (i.e., healings). In Experiment 2, this interpretation bias was affected by the overall treatment-outcome contingency, suggesting that the tendency to interpret ambiguous stimuli as outcomes is learned and context-dependent. In conclusion, we show that, to understand how judgments of effectiveness are affected by outcome probability, we need to also take into account the variable tendency of people to interpret ambiguous information as outcome occurrences.