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nuromuscular blocking agents

European Journal of Anaesthesiology (1)

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A pharmacokinetic-dynamic explanation of the rapid onset–offset of rapacuronium
J. H. Proost, P. M. C. Wright
Journal:

European Journal of Anaesthesiology / Volume 18 / Issue S23 / November 2001

Published online by Cambridge University Press:

16 August 2006, pp. 83-89

Print publication:

November 2001
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The rapid onset and offset of rapacuronium can be explained from its pharmacokinetic and pharmacodynamic characteristics. A unique property of rapacuronium is its high value for ke0, indicating a rapid access to the receptor site. The reason for this high ke0 may be related to the low intrinsic potency of rapacuronium, but this is not yet fully clarified.