We focus on a subdiffusion–reaction system in which substances are separated at the
initial moment. This system is described by nonlinear differential subdiffusion–reaction
equations with a fractional time derivative. These equations are very difficult to solve
but there exist methods which allow us to solve them approximately. We discuss how useful
such methods are, in particular, the quasistatic approximation method and the perturbation
method in analytical solving subdiffusion–reaction equations.