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1 results

  • 3 - Neuropsychopharmacology: the interface between genes and psychiatric nosology

  • from Part II - Clinical background and research design
  • Edited by Bernard Lerer, Hadassah-Hebrew Medical Center, Jerusalem
  • Book:
    Pharmacogenetics of Psychotropic Drugs
    Published online:
    20 August 2009
    Print publication:
    29 August 2002, pp 36-56

  • Summary

    Neuropsychopharmacology has the unique capability of linking the effect of a psychotropic drug on mental illness with the effect of the substance on brain structures involved in the action mechanism of the drug. To provide orientation points about what nosology could offer genetic research, the history of psychiatric nosology is reviewed and the varying constructs that can be used are illustrated. The use of nosologic homotypes derived by the employment of a specially devised nosologic matrix is recommended for obtaining interpretable findings. The data collected by using the nosologic matrix also serves as the starting point for the development of an empirically derived, pharmacologically meaningful classification of mental illness. Genetic heterogeneity, coupled with heterogeneity in pharmacological responsiveness, has also precluded meaningful research with the employment of 'forward genetics' in schizophrenia and manic-depressive illness.