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  • 13 - Is there a role for social factors in a comprehensive development model for schizophrenia?

    • By Jane Boydell, Institute of Psychiatry King's College London, UK, Jim van Os, Maastricht University, Maastricht, the Netherlands, Robin M. Murray, Institute of Psychiatry King's College London, UK
  • Edited by Matcheri S. Keshavan, University of Pittsburgh, James L. Kennedy, Clarke Institute of Psychiatry, Toronto, Robin M. Murray, Institute of Psychiatry, London
  • Book:
    Neurodevelopment and Schizophrenia
    Published online:
    04 August 2010
    Print publication:
    18 November 2004, pp 224-247

  • Summary

    In the 1950s and 1960s, there was much extravagant discussion of the role of social factors in the etiology of schizophrenia. A decade later, the neurodevelopmental model of schizophrenia was proposed, and it became the dominant etiological and pathogenetic model. This chapter reviews the social factors that are postulated to operate early in life and those which may act more proximal to the onset of the disorder. It considers how animal research has informed on psychiatric conditions. Studies using intensive field methods to examine subjective experience of stress in the flow of daily life have found that individuals with schizophrenia, and individuals with genetic susceptibility to schizophrenia, display greater levels of emotional reactivity to small daily life stressors than do control subjects. The chapter also presents the evidence that early social adversity can affect brain development.