This paper relaxes assumptions defining multivariate Brownian motion (BM) to construct processes with dependent increments as tractable models for problems in engineering and management science. We show that any Gaussian Markov process starting at zero and possessing stationary increments and a symmetric smooth kernel has a parametric kernel of a particular form, and we derive the unique unbiased, jointly sufficient, maximum-likelihood estimators of those parameters. As an application, we model a single-server queue driven by such a process and derive its transient distribution conditional on its history.