The coronavirus 2019 (COVID-19) outbreak in China rapidly spread throughout the world, becoming a threatening pandemic with unprecedented consequences. Mobile technologies have led to a revolution in health and their applicability in the context of COVID-19 is promising. In this commentary, we provide an overview of the role that mobile technologies play in the COVID-19 pandemic context and discuss the main issues associated. Four main domains stood out: health communication, prevention, support and research. Strengthening local surveillance systems, geographic contact tracing, support for clinical practice and data collection of real-time longitudinal data at the population level are some of the main advantages of the applications reported so far. The potential conflict to data privacy urges for discussion on their use in a responsible manner. Along with fair regulation and close monitoring of data collection and process, data anonymisation must be a standard and personal data must be deleted after its usage. Preparation is key for effective containment of a public health crisis and learning lessons on the role of mobile technologies is useful for future challenges in global health. It is noteworthy that their use must be driven by an equitable and inclusive orientation, and mostly integrated into an articulated policy to respond to the crisis.