Targets with microstructured front surfaces have shown great potential in improving high-intensity laser–matter interaction. We present cone-shaped microstructures made out of silicon and titanium created by ultrashort laser pulse processing with different characteristics. In addition, we illustrate a process chain based on moulding to recreate the laser-processed samples out of polydimethylsiloxane, polystyrol and copper. With all described methods, samples of large sizes can be manufactured, therefore allowing time-efficient, cost-reduced and reliable ways to fabricate large quantities of identical targets.