The article calls on academics and policymakers who focus on mass atrocity prevention to engage with Trust Studies. This is needed because trust and distrust are commonly identified as a significant factor in destruction processes, yet there remains no substantive engagement with these concepts. The article combines Trust Studies, interdisciplinary research on the Central African Republic (Anthropology, Sociology, African Studies, and Political Science), and primary sources to analyse social and political trust dynamics through an exploration of (a) leadership, (b) outsourcing, (c) identity politics, and (d) witchcraft. It makes a twofold contribution. First, it provides a more informed understanding of the mass violence that took place in the Central African Republic through a historical analysis of trust dynamics. Second, it considers the implications for mass atrocity prevention, as it argues that the mainstream commitment to ‘rebuilding trust’ is built on misguided assumptions. The case study holds broader implications for both Trust Studies and mass atrocity prevention. Ultimately, it calls for interdisciplinary research to aid our collective understanding of the multifaceted roles that trust and distrust play in mass violence.