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liver tolerance

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1 results

Immune response to bovine viral diarrhea virus—looking at newly defined targets
Christopher C. L. Chase, Neelu Thakur, Mahmoud F. Darweesh, Susan E. Morarie-Kane, Mrigendra K. Rajput
Journal:

Animal Health Research Reviews / Volume 16 / Issue 1 / June 2015

Published online by Cambridge University Press:

08 June 2015, pp. 4-14
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Bovine viral diarrhea virus (BVDV) has long been associated with a wide variety of clinical syndromes and immune dysregulation, many which result in secondary bacterial infections. Current understanding of immune cell interactions that result in activation and tolerance are explored in light of BVDV infection including: depletion of lymphocytes, effects on neutrophils, natural killer cells, and the role of receptors and cytokines. In addition, we review some new information on the effect of BVDV on immune development in the fetal liver, the role of resident macrophages, and greater implications for persistent infection.