Field studies were conducted from 2004 to 2006 to evaluate the tolerance of three annual medic species (bur, black, and barrel medic) to selected POST herbicides. 2,4-DB at 0.56 and 1.12 kg/ha caused the most stunting across all three species. Imazethapyr at 0.1 kg/ha stunted all three annual medics in 1 of 3 yr whereas flumetsulam at 0.04 kg/ha stunted black and barrel medics in 1 of 3 yr. Clethodim at 0.28 kg/ha did not cause any medic stunting. Imazethapyr, imazamox, and 2,4-DB at 0.56 kg/ha reduced henbit dry matter composition compared to the untreated check whereas clethodim, flumetsulam, and 2,4-DB at 1.12 kg/ha did not. In 2004, 2,4-DB at 1.12 kg/ha reduced dry weight yield of bur and barrel medic but not black medic when compared with the untreated check. Black medic treated with imazethapyr at 0.05 and 0.1 kg/ha and clethodim at 0.28 kg/ha produced higher dry weight yield than the untreated check. In 2006, both rates of 2,4-DB and flumetsulam at 0.04 kg/ha reduced dry weight yield of bur medic compared to the untreated check. Barrel medic dry weight yields were reduced by both rates of 2,4-DB and flumetsulam compared to untreated check. No herbicides reduced dry weight yields of black medic.