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lactation insufficiency

Journal of Dairy Research (1)

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An endocrine hypothesis to explain obesity-related lactation insufficiency in breastfeeding mothers
Christopher H. Knight
Journal:

Journal of Dairy Research / Volume 87 / Issue 1 / February 2020

Published online by Cambridge University Press:

11 February 2020, pp. 78-81

Print publication:

February 2020
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In this Research Reflection I shall develop and validate the hypothesis that lactation insufficiency in obese breastfeeding mothers has an endocrine explanation. I shall not present data, but I shall review pertinent literature to show that obesity is associated with a partial or sometimes complete failure to initiate and maintain lactation, and critically examine the belief that this is due to psychosocial factors, a failure of prolactin secretion or both. Since progesterone is inhibitory to lactogenesis and oestrogens are inhibitory to milk secretion, I shall then explore the possibility that these steroids are linked to lactation failure, through sequestration of progesterone and aromatization of oestrogen in mammary adipose tissue. I shall conclude by describing experimental approaches in animal models that could be used to test this hypothesis.