This article examines the complex relationship between Sufism, secularity, and psychiatry through Refik Halid Karay’s 1956 novel, Kadınlar Tekkesi (Women’s Lodge). The article argues that Kadınlar Tekkesi recontextualizes Sufism by medicalizing and pathologizing it through psychiatry and psychopathology. This analysis draws upon discourse analysis and Michel Foucault’s exploration of abnormality and power dynamics. The article contends that this approach diverges from previous anti-Sufi agendas of Turkish novels, which were primarily motivated by religious and moralistic criticisms. The article argues that the application of psychiatric terminology to Sufism suggests a shift in Turkish secularism’s attitude toward Sufism, which transitions from dismissing Sufism as obsolete to engaging with it systematically through scientific study. Informed by modern scientific rationality, this shift signifies a redefined interaction between knowledge and power and the gendered aspects of the medicalization process. The article underscores that interactions between the discourses of secularism, Sufism, and psychopathology suggest a new regime of truth based on secular and scientific thought, while implicitly supported by orthodox Islamic principles.