African scholarship on epistemic decolonization and African self-determination has generated reflection and debate among African Studies scholars for several decades. The debate has gained new force in recent years and has resonated in African studies in new ways, prompted in part by political events and social activism around enduring racism. Grosz-Ngaté’s 2019 Presidential Lecture provides an opportunity to reflect further on these issues. It explores questions related to the production and decolonization of knowledge in conversations with colleagues in Mali and Senegal and draws out the implications of these discussions for African Studies Association members and for the Association at large.