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immune-mediated necrotising myopathy

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1 results

Case 61 - Immune-Mediated Necrotizing Myopathy (IMNM)
from Myopathies
Jessica E. Hoogendijk, University Medical Center Utrecht, Marianne de Visser, Amsterdam University Medical Center, Pieter A. van Doorn, Erasmus MC, University Medical Center, Rotterdam, Erik H. Niks, Leiden University Medical Center
Book:

Neuromuscular Disease

Published online:

29 November 2024

Print publication:

19 December 2024, pp 252-255
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Summary

At the age of 44 years, this now 57-year-old woman noticed myalgia and difficulty walking, progressing over weeks. Two weeks after the first complaints, lifting the arms became troublesome too. CK activity was found to be > 10,000 U/L. TSH was normal. A diagnosis of myositis was made, and prednisone was started at a dose of 60 mg daily (body weight 80 kg). CK decreased, but the complaints worsened. Six weeks after disease onset, she was presented at our hospital. She was otherwise healthy, apart from well-controlled Graves disease with orbitopathy at the age of 31 years.