In a repeated multi-year study, mother potato plants were exposed to herbicides at rates that simulated off-target application, such as through tank contamination. Following exposure of mother plants to herbicides, seed from mother plants was planted in the following growing season and crop growth, yield and tuber quality were quantified. Visual injury from herbicides was observed both in the mother plant and daughter tuber growing seasons and occasional impacts on tuber yield were noted. However, an inconsistent relationship was observed for herbicide related injury and tuber yield reductions of mother potato plants with daughter tuber growth and yield. The lack of consistency in the relationship between visual potato injury in the mother plant production and adverse daughter tuber growth and yield in the following year challenges traditional crop scouting as a tool to predict off-target herbicide risk near seed potato production.