The combination of certain herbicides with insecticides can inhibit crop growth. Greenhouse studies were conducted to evaluate interaction effects of herbicides and insecticides with/without protectant, on corn and weed species. ‘Northrup King 9283’ hybrid corn showed greater sensitivity to acetanilide herbicides than ‘Cargill 7567.’ Neither the insecticides terbufos nor isazofos appeared to enhance this sensitivity. Both hybrids were sensitive to the combination of chlorimuron, nicosulfuron, or primisulfuron with terbufos. Cargill 7567 was more tolerant than Northrup King 9283 to the growth inhibiting interaction of sulfonylurea herbicides with terbufos. Imazaquin at 70 g/ha reduced height of Northrup King 9283 corn, but there was no interaction with terbufos. The protectants CGA-154281 and NA reduced corn injury from metolachlor and the combination of nicosulfuron and primisulfuron with terbufos, respectively. Nicosulfuron and primisulfuron treatments combined with metolachlor showed less corn injury than metolachlor alone, but these herbicides increased corn injury when combined with terbufos. The inclusion of terbufos did not enhance primisulfuron activity on barnyardgrass, giant foxtail, or velvetleaf.