The efficacy of two applications of several PRE herbicides for extended control of long-stalked phyllanthus and leafflower were evaluated under container nursery conditions at two climatically different sites in Florida. Prodiamine at 4.5 kg ai/ha provided the longest and most consistent reductions in number, percent coverage (visual) of the medium, and dry weight of both species. Ten weeks of excellent PRE control (percent medium coverage ≤ 10%; number of weeds reduced by ≥ 70%) of both species was obtained at one site after the first and second applications of prodiamine at 2.2 or 4.5 kg ai/ha; two applications were required at the second site for similar control. Rates of the other herbicides were generally too low for excellent control of both species after one application, the exceptions being dithiopyr at 4.5 kg ai/ha and the preformulated combination of isoxaben and oryzalin (1.1 and 3.4 kg ai/ha, respectively). These herbicides provided good (10% < percent medium coverage ≤ 20%; number of weeds reduced by ≥ 70%) to excellent PRE control of long-stalked phyllanthus after the first and second applications at one site. Percent coverage of the medium by either species in untreated containers was 96 to 100%.