Increased focus on sustainability significantly impacts product development portfolio management in organizations. This paper focuses on the significant unaccommodated uncertainty caused by the green transition for current mid- and long-term portfolio management processes. These uncertainties arise in areas such as the regulatory environment, market demands, and technical capabilities. This paper makes four contributions: First, current product portfolio management literature is mostly employing deterministic practices. Uncertainties are incompletely addressed, and current methods fail to address the deep uncertainties of the green transition. Second, building a literature-based conceptual framework of the sources of uncertainty in 6 areas: Business Models, Technology, Regulation and Legislation, Finance and Insurance, Market and Consumer, and Organizational Context. Third, preliminary empirical evidence supports the usefulness of our model for product development portfolio management. Fourth, concluding with a suggested empirical research agenda to develop a deeper understanding of challenges towards method and theory development to support the green transition on the portfolio management level.