This article is concerned with interregional trade dynamics between Elam and Mesopotamia in the early to mid-first millennium BC. During the seventh century BC, two great famines in the Neo-Elamite kingdom, of which climatological changes were a major cause, were documented in the textual records. An era of megadrought made grain procurement from the neighboring regions essential to feed the Neo-Elamite lowland population. This article further explores the impact of the two Neo-Elamite famines and “drought of the century” on the commercial and political mechanisms in the Upper Persian Gulf region.