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1 results

  • 10 - What makes ‘good sperm’?

  • from SECTION 2 - THE EMBRYO
  • Edited by Hilary Critchley, University of Edinburgh, Iain Cameron, University of Southampton, Stephen Smith
  • Book:
    Implantation and Early Development
    Published online:
    05 June 2014
    Print publication:
    01 June 2005, pp 119-128

  • Summary

    This chapter discusses the four important measurable aspects of sperm function that define a good sperm: sperm transport, sperm-epithelial contact, sperm-egg recognition and fertilisation, and DNA quality. One of the important aspects of sperm transport to emerge over the past ten years is the role of sperm-epithelial contact in regulating sperm physiology during the preovulatory period. It has been shown that co-culture of sperm with epithelium from the human endosalpinx prolongs sperm viability, increases motility and delays the process of sperm capacitation. Whether fertilisation occurs in vitro or in vivo, it is almost certain that the cellular and molecular processes of sperm-egg recognition and fertilisation are identical. Studies of sperm DNA quality have shown that DNA integrity is directly related to the probability of conception, both in the general population and in couples attending for assisted conception treatment.