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  • Edward Maxwell (Max) Nicholls (1927–2011), a Key Player in the Development of the Two-Hit Model of Tumor Formation

  • Alan E. Stark, Paulo A. Otto
  • Journal:
    Twin Research and Human Genetics / Volume 19 / Issue 4 / August 2016
    Published online by Cambridge University Press:
    15 June 2016, pp. 402-403
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  • E. M. Nicholls (1927–2011) was a humanist, medical practitioner, human biologist, geneticist and, above all, a teacher, as well as a husband and father. He believed that he had made a fundamental contribution to the two-hit model of cancer formation. This hypothesis is associated with retinoblastoma, in particular. Nicholls presented it through his observations on neurofibromatosis. He received little credit for what he believed was his most original contribution to medical science. This note attempts to redress the balance in his favor.