The main question this chapter asks and attempts to answer is: What is the principal difference between animal life and human spirit, as Hegel construes it at the end of his Philosophy of Nature? More specifically, in what way are non-human animal organisms “inadequate” or “imperfect” and in what way, correspondingly, are human beings the “perfect” animal? Answering this question requires getting clear on the different ways in which non-human and human animals bear their respective natures, the connection between reproduction and the manner in which non-human animals relate to their genus, and the role of biological death within that process of reproduction. To the extent that Hegel commentators have dealt with the relation between animal life and human spirit, they have been predominantly concerned in recent years with Hegel’s Anthropology. The end of the Philosophy of Nature has, by contrast, been relatively neglected. On the occasions when it has been discussed, the latter text has tended to be the object of passing paraphrase rather than the focus of an attempt at philosophical comprehension. This chapter contributes to remedying this scholarly situation.