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1 results

  • 6 - Genetic aspects

  • Edited by Helmut Remschmidt, Philipps-Universität Marburg, Germany
  • Book:
    Schizophrenia in Children and Adolescents
    Published online:
    23 October 2009
    Print publication:
    23 November 2000, pp 119-134

  • Summary

    Most genetic research to date concerns adult subjects with schizophrenia, and there is a relative dearth of information regarding the genetics of the childhood onset disorder. This chapter draws on evidence from adults as well as from the small amount of literature pertaining specifically to children. An earlier onset of schizophrenia might result from an increased genetic load or a more potent environmental insult, and would therefore be expected to result in increased familiality. Adoption studies allow the separation of the effects of genes and family environment. There are three commonly used methods such as: adoptee study, adoptee's family study and cross-fostering study. Various genetic mechanisms have been offered as explanations of the similarity between relatives in liability to schizophrenia. Alternative modes of inheritance may involve many genes of small effect, with or without an environmental effect.