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2 results

  • Fetal CHD and perinatal outcomes

  • Christina J. Ge, Amanda C. Mahle, Irina Burd, Eric B. Jelin, Priya Sekar, Angie C. Jelin
  • Journal:
    Cardiology in the Young / Volume 30 / Issue 5 / May 2020
    Published online by Cambridge University Press:
    20 April 2020, pp. 686-691
  • Objective:

    To evaluate delivery management and outcomes in fetuses prenatally diagnosed with CHD.

    Study design:

    A retrospective cohort study was conducted on 6194 fetuses (born between 2013 and 2016), comparing prenatally diagnosed with CHD (170) to those with non-cardiac (234) and no anomalies (5790). Primary outcomes included the incidence of preterm delivery and mode of delivery.

    Results:

    Gestational age at delivery was significantly lower between the CHD and non-anomalous cohorts (38.6 and 39.1 weeks, respectively). Neonates with CHD had a significantly lower birth weights (p < 0.001). There was an approximately 1.5-fold increase in the rate of primary cesarean sections associated with prenatally diagnosed CHD with an odds ratio of 1.49 (95% CI 1.06–2.10).

    Conclusions:

    Our study provides additional evidence that the prenatal diagnosis of CHD is associated with a lower birth weight, preterm delivery, and with an increased risk of delivery by primary cesarean section.

  • Congenital Malformations Associated With a Single Umbilical Artery in Twin Pregnancies

  • Sarah E. Mitchell, Karen Reidy, Fabricio Da Silva Costa, Ricardo Palma-Dias, Thomas J. Cade, Mark P. Umstad
  • Journal:
    Twin Research and Human Genetics / Volume 18 / Issue 5 / October 2015
    Published online by Cambridge University Press:
    20 August 2015, pp. 595-600
    • Article
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  • A single umbilical artery (SUA) was identified in 1.5% of twin pregnancies. The presence of a SUA in a twin pregnancy was associated with a 50% incidence of fetal anomalies, many of them complex and severe. The embryology and pathophysiological mechanisms associated with a SUA are reviewed. Aneuploidy is relatively common and should be considered, particularly in the presence of associated anomalies. Fetal growth restriction is frequent and preterm delivery is common.