This chapter focuses on psychosocial factors in child and adolescent onset schizophrenia with the goal of highlighting promising psychosocial treatment strategies. It deals with psychosocial functioning and developmental progressions of schizophrenia in adolescence. The chapter reviews the treatment strategies for schizophrenia in adolescents. Despite the dearth of controlled treatment trials for adolescents suffering from schizophrenia, accumulating clinical and research data highlight some major issues with respect to the treatment of schizophrenia in adolescent. Three primary psychosocial intervention approaches investigated for adults with schizophrenia include (i) individual psychotherapy, (ii) family-focused interventions, and (iii) skills building strategies. There is an urgent need for additional research to clarify optimal treatment strategies for adolescents with schizophrenia. The chapter turns to the implications of current knowledge for the psychosocial treatment of adolescents with schizophrenia, and concludes by offering suggestions regarding future directions for clinical research and treatment.