The duration and intensity of unicorn-plant interference on lint yield of cotton were evaluated in the field. Random densities of 5.5 ± 1.1 unicorn-plant/m2 reduced lint yield by 41 kg/ha or about 5% for each week that unicorn-plant was present. Interference by 4, 8, and 12 weeds/10 m row decreased yield by 22, 49, and 56 kg/ha, respectively, for each week of weed interference. Each 1 kg/ha of unicorn-plant dry weight reduced lint yield by 0.26 kg/ha. Linear regression of weed dry weight could be used to predict cotton lint yield changes regardless of duration or intensity of weed interference.