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2 results

  • Sperm-derived factors enhance the in vitro developmental potential of haploid parthenotes

  • Ramya Nair, Shahin Aboobacker, Srinivas Mutalik, Guruprasad Kalthur, Satish Kumar Adiga
  • Journal:
    Zygote / Volume 25 / Issue 6 / December 2017
    Published online by Cambridge University Press:
    28 November 2017, pp. 697-710

  • Parthenotes are characterized by poor in vitro developmental potential either due to the ploidy status or the absence of paternal factors. In the present study, we demonstrate the beneficial role of sperm-derived factors (SDF) on the in vitro development of mouse parthenotes. Mature (MII) oocytes collected from superovulated Swiss albino mice were activated using strontium chloride (SrCl2) in the presence or absence of various concentrations of SDF in M16 medium. The presence of SDF in activation medium did not have any significant influence on the activation rate. However, a significant increase in the developmental potential of the embryos and increased blastocyst rate (P < 0.01) was observed at 50 µg/ml concentration. Furthermore, the activated oocytes from this group exhibited early cleavage and cortical distribution of cortical granules that was similar to that of normally fertilized zygotes. Culturing 2-cell stage parthenotes in the presence of SDF significantly improved the developmental potential (P < 0.05) indicating that they also play a significant role in embryo development. In conclusion, artificial activation of oocytes with SDF can improve the developmental potential of parthenotes in vitro.

  • Chapter 10 - Developmental potential

  • Edited by Tuomas E. Tahko, University of Helsinki
  • Book:
    Contemporary Aristotelian Metaphysics
    Published online:
    05 December 2011
    Print publication:
    08 December 2011, pp 156-173

  • Summary

    This chapter introduces, from an ontological point of view, the definition: development is a self-directed epigenetic process consisting of sequential phase changes, consequent on interaction of genome, epigenetic systems, and external environment, which transform a living thing into successive stages of an individual of its kind. A developmental potential is a type of capacity-developing capacity. The chapter undertakes to model an illustrative case, prenatal manifestation of human developmental potentials. It seeks a probabilistic model countenanceable not only within multipredicative monism, but when generalized, within rival ontological views on dispositions. We observe that acquisition of a capacity may occur gradually and involve the sequential acquisition of properties. We have introduced developmental potential as a capacity to develop a capacity, characterized such a capacity as a propensity, and related how a probability distribution may be said to project an organism's bounded set of such propensities.