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Alphavirus replicon vaccines
Ryan L. Vander Veen, D. L. Hank Harris, Kurt I. Kamrud
Journal:

Animal Health Research Reviews / Volume 13 / Issue 1 / June 2012

Published online by Cambridge University Press:

21 March 2012, pp. 1-9
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The alphavirus replicon technology has been utilized for many years to develop vaccines for both veterinary and human applications. Many developments have been made to the replicon platform recently, resulting in improved safety and efficacy of replicon particle (RP) vaccines. This review provides a broad overview of the replicon technology and safety features of the system and discusses the current literature on RP and replicon-based vaccines.