Non-alcoholic fatty liver disease (NAFLD) is now the leading cause of chronic liver disease, affecting approximately 30% of people worldwide. Histopathology reading of fibrosis patterns is crucial to diagnosing NAFLD. In particular, separating mild from severe stages corresponds to a critical transition as it correlates with clinical outcomes. Deep Learning for digitized histopathology whole-slide images (WSIs) can reduce high inter- and intra-rater variability. We demonstrate a novel solution to score fibrosis severity on a retrospective cohort of 152 Sirius-Red WSIs, with fibrosis stage annotated at slide level by an expert pathologist. We exploit multiple instance learning and multiple-inferences to address the sparsity of pathological signs. We achieved an accuracy of $ 78.98\pm 5.86\% $, an F1 score of $ 77.99\pm 5.64\%, $ and an AUC of $ 0.87\pm 0.06 $. These results set new state-of-the-art benchmarks for this application.

This paper proposes a novel approach for lossless coding of light field (LF) images based on a macro-pixel (MP) synthesis technique which synthesizes the entire LF image in one step. The reference views used in the synthesis process are selected based on four different view configurations and define the reference LF image. This image is stored as an array of reference MPs which collect one pixel from each reference view, being losslessly encoded as a base layer. A first contribution focuses on a novel network design for view synthesis which synthesizes the entire LF image as an array of synthesized MPs. A second contribution proposes a network model for coding which computes the MP prediction used for lossless encoding of the remaining views as an enhancement layer. Synthesis results show an average distortion of 29.82 dB based on four reference views and up to 36.19 dB based on 25 reference views. Compression results show an average improvement of 29.9% over the traditional lossless image codecs and 9.1% over the state-of-the-art.