1 Introduction
2 The Complex Construct of Computer Simulations
3 Why Use Computer Simulations?
3.1 Practical Considerations
3.2 Conceptual Understanding
3.3 Procedural Skill Development
3.4 Science Skills and Practices
3.5 Systems and Systems Thinking
4 Cyber Behavior and Student Learning with Computer Simulations
4.1 Learner Variables
4.2 Teachers Matter
4.2.1 Instructional Support
4.2.2 Inquiry-Based Use
5 Software Design Considerations
6 Teacher Education and Simulation Adoption
7 New Directions: Science Computer Simulations and Cyber Behavior
7.1 Realism
7.2 Nature of Science
7.3 Engineering
7.4 Computational Thinking
7.5 Remote Learning
7.6 Assessment
8 Future Directions for Research
9 Conclusion